Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversity of Social Sciences and Humanities, Warsaw

About this trial

The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs). Intervention will involve the prior presentation of the most aversive fragment of the memory, the so-called 'hotspot.' This intervention will allow for the replication of the effect described by Dibbets and Arntz (2016), according to which the prior activation of the most emotional element of a memory enhances the effectiveness of ImRs.

The study is also significant due to another ongoing study in which a substantial number of participants have already been examined; however, due to the exhaustion of funds, it was not possible to utilize the remainder of the recruited sample. Investigating an additional condition will allow for a more complete utilization of the available participant pool and significantly increase the project's scientific value by comparing the traditional ImRs mechanism with its AI-generated version.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18-35

Score ≥ 8 on GAD-7 (Plummer et al., 2016)

Ability to recall at least two childhood memories involving parental criticism

Disqualifiers

History of prolonged physical or sexual abuse

Current psychotherapy or psychopharmacology

PTSD diagnosis (DSM-5 screening)

Substance abuse (TAPS tool)

Trial design

Design model

Single group

Treatments tested in this trial

  • Imagery Rescripting Intervention

    Behavioral

    Participants listened to a series of personalized audio scenarios based on their childhood memories of parental criticism and neutral events. At the end of the session, one critical scenario was presented in a modified version that included a therapeutic imagery rescripting (ImRs) intervention. In this script, a therapist figure entered the scene and addressed the child's unmet needs, following the standard rescripting format. The scripts were generated using the Gemini large language model and reviewed by trained experimenters to ensure coherence and therapeutic validity. The intervention aimed to reduce distress and intrusive thoughts related to the memory.

Treatment groups

40 Participants
are divided into 1 treatment group
Group A: ImRs AIExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Generalized Anxiety Disorder DSM Scale (GAD)

DSM Scale (Craske et al., 2013, own translation); brief dimensional self-rating questionnaire for generalized anxiety disorder (American Psychiatric Association, 2013, Polish translation: translation made by the authors using a standard back-translation method, 2020). Scale consists of 10 items relating to the thoughts, feelings, and behaviors the subjects have experienced in the last 7 days. The answers are marked on a 4-point Likert scale (0=never, 4=all the time), with scores ranging 0-4.

Time frame
Screening, Pre-intervention (Day 1) and 1-week follow-up
2

The Performance Failure Appraisal Inventory

The Performance Failure Appraisal Inventory was used to assess fear of failure. It is a 25-item questionnaire that measures the strength of subjective beliefs about the consequences of failure. The PFAI has five subscales: fear of experiencing shame and embarrassment; fear of devaluing one's self-esteem; fear of having an uncertain future; fear of important others losing interest; and fear of upsetting important others. PFAI score ranges from 35 to 175, with higher scores indicating a higher level of fear of failure.

Time frame
Pre-intervention (Day 1)
3

Intrusive Thought Frequency (Rumination Inventory - adapted)

A modified version of the Event-Related Rumination Inventory will be used to assess the frequency and intrusiveness of thoughts related to the autobiographical criticism memories. The scale includes both intrusive and reflective rumination items, ranging from 20 to 80, with higher scores indicating a higher level of event-related rumination. Change in scores between baseline and follow-up will serve as an index of the cognitive impact of the intervention.

Time frame
Pre-intervention (Day 1) and 1-week follow-up
4

Skin Conductance Level (SCL)

Electrodermal activity will be recorded continuously during the presentation of autobiographical scenarios to assess physiological arousal. The SCL signal will be analyzed during the baseline, critical, and neutral conditions, as well as during the imagery rescripting (ImRs) intervention (experimental group only). Data will be used to examine whether AI-generated criticism scripts elicit arousal.

Time frame
During experiment/intervention (Day 1)

Secondary outcomes

1

Therapist Ratings of Script Quality

A panel of cognitive-behavioral therapists will rate the AI-generated and manually created scripts on a 10-point Likert scale ranging from 1 to 20, for therapeutic quality, coherence, and emotional relevance. Higher scores will indicate higher quality/coherence/emotional relevance. Average therapist ratings will be used to test hypotheses about the acceptability of LLM-generated therapeutic content.

Time frame
Prior to intervention
2

Questionnaire on the Perceived Effectiveness and Appropriateness of Imagery-Based Intervention

A custom-developed questionnaire will be administered to participants in the experimental group to assess their subjective evaluation of the imagery rescripting intervention. The measure includes items evaluating emotional intensity, difficulty with imagery, resistance to memory modification, trust in the therapeutic process, realism of the experience, and other affective and cognitive responses. Items are rated on 5-point Likert scales and grouped into subscales representing common therapeutic barriers and facilitators. Each subscale ranges from 4 to 20, with a higher score indicating a higher problem with imagery techniques. The total and subscale scores will be analyzed to explore which factors are associated with intervention acceptance and perceived effectiveness.

Time frame
Post-intervention (Day 1)
3

TAPS Tool - Substance Use Screening

The Tobacco, Alcohol, Prescription Medication, and Other Substance Use Tool (TAPS) will be used to screen for problematic substance use. The self-report version of the TAPS consists of two parts: (1) past 12-month use of tobacco, alcohol, illicit drugs, and prescription medication for non-medical use. Scores will range from 1 (never) to 5 (every day/almost every day), with higher scores indicating a greater frequency of substance use. Scores will be used to exclude participants with probable substance use disorders, in line with the study's eligibility criteria.

Time frame
Screening only
4

Post-Traumatic Stress Symptoms Scale (DSM)

Self-report scale assessing PTSD symptoms as defined by DSM-5 criteria. The instrument includes 10 items evaluating symptom frequency over the previous 7 days on a 0-4 Likert scale. Total scores range from 0 to 40.

Time frame
Screening only

Other outcomes

1

Beck Depression Inventory

The Beck Depression Inventory, Second Edition (BDI-II), is a 21-item self-report questionnaire assessing the severity of depressive symptoms, with total scores ranging from 0 to 63. Higher scores indicate higher levels of depressive symptoms. In this study, the BDI-II was administered at screening to assess baseline depressive symptoms. While not used as a formal outcome variable, BDI-II scores may be included in exploratory analyses to examine their potential moderating effects on emotional responses or intervention acceptance.

Time frame
Screening only

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