Health TrialsbyHealthPanel

Optimization Strategy of Carotid Artery Stenosis

ConditionCarotid Artery Stenosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPeking Union Medical College Hospital

About this trial

The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy.

The main questions it aims to answer are:

* Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion. * Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques.

Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram;

patients received carotid endarterectomy at Peking Union Medical College Hospital

Disqualifiers

None

Trial population

Mild to severe carotid stenosis or near-occlusion patients receiving carotid revascularization treatment.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Carotid revascularization

    Procedure/Surgery

    All patients received carotid revascularization surgery at Peking Union Medical College Hospital.

  • MRI-PWI

    Diagnostic test

    Multi-modal MRI before and after surgery.

  • CTA

    Diagnostic test

    CTA before and after surgery.

  • PET/MRI

    Diagnostic test

    PET/MRI before surgery.

  • Ultrasound

    Diagnostic test

    Ultrasound before and after surgery.

Treatment groups

1,000 Participants
are divided into 1 treatment group
Group A: Carotid artery stenosis5 interventions

Trial outcomes

Primary outcomes

1

stroke

perioperative stroke

Time frame
During hospital stay, usually 7-30 days post operation
2

cardiac infarction

perioperative cardiac infarction

Time frame
During hospital stay, usually 7-30 days post operation
3

transient ischemic attack

perioperative transient ischemic attack

Time frame
During hospital stay, usually 7-30 days post operation
4

cerebral hyperperfusion syndrome

perioperative cerebral hyperperfusion syndrome

Time frame
During hospital stay, usually 7-30 days post operation

Secondary outcomes

1

Image characters of MRI

Arterial transit times, cerebral blood flow, plaque characters, etc.

Time frame
half year after operation
2

Image characters of PET/MRI

Diagnostic performance of 68Ga-FAPI PET/MR for intracranial or carotid atherosclerosis

Time frame
half year after operation
3

Image characters of ultrasound

Diagnostic performance of carotid artery ultrasound for intracranial or carotid atherosclerosis

Time frame
half year after operation
4

Carotid plaque characters

pathology characters of carotid plaque

Time frame
half year after operation

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Peking Union Medical College Hospital

Lead sponsor

Source ClinicalTrials.gov
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