Health TrialsbyHealthPanel

Optimizing Bronchopulmonary Cancer Screening

ConditionsBronchopulmonary DiseaseDiagnoses Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50-74
SponsorInstitut Curie

About this trial

The aim of this study is to evaluate the feasibility of performing a first screening for bronchopulmonary cancer by thoracic scanner in a French cohort within a dedicated, effective and structured network in the pilot centers participating in the study.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Participant aged 50 to 74.

Resident in the Île-de-France region.

more than 10 cigarettes a day for more than 30 years,

more than 15 cigarettes a day for more than 25 years.

Disqualifiers

Active cancer or a history of cancer in remission for less than 5 years (except basal cell carcinoma of th skin or epithelioma in situ of the uterine cervix).

Presence of symptoms suggestive of bronchopulmonary cancer. Participants with these symptoms require immediate diagnostic investigations and are therefore not eligible for screening.

Weight >= 140 kg.

Severe comorbidity contraindicating therapeutic options or invasive thoracic diagnostic investigations.

Trial design

Design model

Single group

Treatments tested in this trial

  • Screening

    Other intervention

    A first step to identify and recruit people eligible for screening,

  • Inclusion

    Other intervention

    A second step for inclusion of participants, with an online self-questionnaire and information, and an inclusion visit to the health center,

  • Chest CTscan and follow-up

    Other intervention

    A third step with an initial CTscan, with dual interpretation and appropriate management of participants, including follow-up care.

Treatment groups

500 Participants
are divided into 1 treatment group
Group A: Screening for primary prevention of bronchopulmonary cancerOther 3 interventions

Trial outcomes

Primary outcomes

1

Rate of first CTscan for bronchopulmonary cancer screening

Rate of completion of a first bronchopulmonary cancer screening among people who have joined the program (i.e. registered on the program's web platform and met the inclusion criteria).

Time frame
36 months

Secondary outcomes

1

Eligibility rate among people registering on the web platform

Ratio of the number of eligible people (meeting all inclusion and inclusion criteria and no non-inclusion criteria) to the total number of people registered on the web platform.

Time frame
36 months
2

Rate of completion of the inclusion visit among people registered on the web platform,

Ratio of the number of people who have completed the inclusion visit to the total number of eligible people registered on the web platform

Time frame
36 months
3

Rate of completion of screening scanners at 1 year according to NELSON trial schedule

Ratio of the number of people who had their 1-year screening CTscan among those eligible for a 1-year CTscan

Time frame
48 months
4

Rate of completion of screening scanners at 3 years according to NELSON trial schedule

Ratio of the number of people who had their 3-year screening CTscan among those eligible for a 3-year CTscan

Time frame
72 months

Other outcomes

Sponsors and contacts

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Institut Curie

Lead sponsor

Institut Mutualiste Montsouris

Collaborator

Source ClinicalTrials.gov
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