Oral Health Condition Among a Group of Ionizing Radiation Field Workers
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age30-40
SponsorAl-Mustansiriyah University
About this trial
The goal of this study is to test the effect of ionizing radiation on salivary Redox status among a group of ionizing radiation workers by measuring salivary biomarkers(malondialdehyde,8\_hydroxy\_deoxyguanosine and catalase) and measuring oral health condition by plaque index.
90 male subjects will be enrolled in this study between 30\_40 years old worked in Baghdad teaching hospital ,30 subjects exposed from computed tomography department ,30 subjects exposed from x\_ray department and 30 subjects unexposed from laboratory department in the same hospitals.
The method of the study is taking unstimulated saliva sample from the subjects and oral health measure.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
male, 30_40 years ,no history of systemic disease, no medical treatment taken at least 3 months before sampling and the subjects are exposed to radiation 5_ 10 years
Disqualifiers
subjects with medical history , subjects are taken medications during last 3 months , the subjects are exposed to radiation less than 5 years or more than 10 years
Trial population
Male workers in radiation field from 30\_40 years old who exposed to radiation for 5\_10 years and compare them with male workers in laboratory at age 30\_40 years
Trial design
Design model
Case-crossover
Time perspective
Cross-sectional
Treatments tested in this trial
Salivary redox biomarkers
RadiationSalivary redox biomarkers
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
oral health status
Changes in the clinical periodontal parameter (Plaque index ) To determine the patients' plaque index, their dental plaque thickness was evaluated by probing the mesial, distal, buccal, and palatal surfaces of all teeth using a Williams periodontal probe. The individual's plaque index was determined by summing the values obtained for each tooth and calculating the averages.Silness \& Löe (Silness \& Löe,1964) reference values were taken as a basis The Plaque Index (PI) scores each site on a 0 to 3 scale Score 0 : No plaque is in the area adjacent to the gingiva. Score 1: There is a plaque in the form of a thin film on the gingival margin. Score 2: There is a visible plaque in the gingival pocket and gingival margin. Score 3: There is a dense plaque in the gingival pocket and on the gingival margin.
Time frame
Baseline: the subjects must be fasting. up to two hours saliva collectionSecondary outcomes
1
Salivary Malondialdehyde biomarker
Measure salivary malondialdehyde biomarker for all 90 subjects (computed tomography,x\_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field
Time frame
Baseline:saliva collection for malondialdehyde . up to two hours fasting for all subjects.2
Salivary 8_ hydroxy_deoxyguanosine biomarker
Measure salivary 8\_hydroxy\_deoxyguanosine biomarker for all 90 subjects (computed tomography,x\_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field
Time frame
Baseline:saliva collection for 8_hydroxy_deoxyguanosine .up to two hours fasting for all subjects.3
Salivary catalase biomarker
Measure salivary catalase biomarker for all 90 subjects (computed tomography,x\_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field
Time frame
Baseline:saliva collection for catalase . up to two hours fasting for all subjects.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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