Oral Microbiota and Muscle Function in the Ageing Subject
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age70+
SponsorUniversity Hospital, Rouen
About this trial
Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities. It affects between 0.7% and 16% of European adults over 70 years of age (1). Recent studies suggest that the faecal microbiota may be altered with ageing but also according to sarcopenic status. Furthermore, no study has currently published data on the relationship between salivary microbiota and sarcopenic status. The main hypothesis of this study is that a decrease in salivary microbiota richness could be associated with impaired handgrip strength in the ageing subject.
Eligibility criteria
Qualifiers
Male or female adult volunteer, over 70 years of age
Non-hospitalised
Having read and understood the information letter and signed the consent form
Affiliated with a Social Security scheme
Disqualifiers
Already included in an interventional drug clinical trial
Unable to understand and complete the questionnaires
Deprived of liberty by an administrative or judicial decision or protected adult subject (under guardianship, curatorship or judicial protection order)
Receiving antibiotic treatment or having received antibiotic treatment during the previous 3 months
Trial design
Treatments tested in this trial
- Salivary and fecal microbiota sampling and muscle strength assessment
Treatment groups
60 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov