Oregano and Basil Leaves and Coronary Artery Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-75
SponsorShahid Beheshti University of Medical Sciences
About this trial
The present study will examine the effects of increasing dietary polyphenol intake by consumption of oregano and basil leaves, on plasma inflammatory and lipid factors and total urinary polyphenol levels in patients who have recently had unstable angina.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients diagnosed with unstable angina
Disqualifiers
Patients diagnosed with STEMI
Patients undergoing coronary artery bypass grafting
Liver cirrhosis and advanced chronic kidney disease (CKD 5)
Having known inflammatory and autoimmune diseases, such as inflammatory bowel disease (IBD) and rheumatoid arthritis, or taking glucocorticoid medications
Trial design
Design model
Parallel
Treatments tested in this trial
Control (Standard treatment)
Other interventionPatients receive standard medical treatment.
Higher polyphenol intake by consumption of oregano and basil
Other interventionPatients consume 4-5 grams of dried oregano and 4-5 grams of dried basil leaves daily for two months in addition to their usual medical treatment.
Treatment groups
70 Participants
are divided into 2 treatment groupsGroup A: ControlOther 1 intervention
Group B: Higher polyphenol intake by consumption of oregano and basilExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Plasma inflammatory biomarkers
Plasma c-reactive protein, Interleukin-6, RANTES (CCL5)
Time frame
At the beginning of the study and two months later2
Plasma lipids
Plasma concentrations of triglyceride, cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol
Time frame
At the beginning of the study and two months laterSecondary outcomes
1
Plasma malondialdehyde
Plasma concentrations of malondialdehyde
Time frame
At the beginning of the study and two months later2
Urinary total polyphenols
Levels total polyphenols in spot urine sample measured by Folin-Ciocalteu method
Time frame
At the beginning of the study and two months later3
Plasma PCSK9 and PAI-1 levels
plasma concentrations of proprotein convertase subtilisin/kexin type 9 (PCSK9) and plasminogen activator inhibitor 1 (PAI-1)
Time frame
At the beginning of the study and two months laterSponsors and contacts
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Source ClinicalTrials.gov