The purpose of this study is to characterize organ dysfunction change in acute necrotizing pancreatitis patients with sepsis after open necrosectomy.
Patients 18 years or older
Diagnosis of Acute pancreatitis according to the revised Atlanta classification, requires two of the following three criteria: (A) typical abdominal pain, (B) an increase in serum amylase or lipase levels higher than three times the upper limit of normality, and (C) signs of AP in imaging
Patients with confirmed or suspected infected pancreatic or peripancreatic necrosis were scheduled for open necrosectomy
Meet Sepsis-3 criteria
Patients refuse to participate
Patients undergo repeat surgery on the same site
Acute necrotizing pancreatitis Patients with sepsis scheduled for open necrosectomy will be invited to participate in this study.
Cohort
Prospective
Necrotizing Pancreatitis patients' organ dysfunction progression
Other interventionStudy the dynamic nature of organ dysfunction
Measure organ dysfunction change after open necrosectomy with respect to time
Organ dysfunction will be measured using sequential organ failure assessment score scale. The scores range from 0 (normal) to 4(most abnormal) for each organ, with higher scores indicating worse health status
incidence of a composite of major complications
Major complications were defined as new-onset organ failure (ie, cardiovascular, pulmonary, or renal)
Incidence of ICU mortality
Death occurred in ICU
Incidence of hospital mortality
Death occurred in hospital
Incidence of 28-day mortality
Death occurred within 28-day after surgery
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Chunling Jiang
Lead sponsor
West China Hospital
Sponsor institution
