ORI-Guided Oxygen Therapy During One-Lung Ventilation
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19+
SponsorKonkuk University Medical Center
About this trial
High inspired oxygen concentrations (FiO₂) are commonly administered during general anesthesia to prevent hypoxemia. However, excessive oxygen administration may result in hyperoxemia, which has been associated with impaired hypoxic pulmonary vasoconstriction, increased oxidative stress, ventilation-perfusion mismatch, and postoperative pulmonary complications.
During one-lung ventilation (OLV) for thoracic surgery, higher FiO₂ is often required because of increased intrapulmonary shunting, making hyperoxemia a frequent occurrence. The Oxygen Reserve Index (ORI) is a noninvasive pulse oximetry-derived parameter that reflects moderate hyperoxemia (PaO₂ approximately 100-200 mmHg) and may facilitate more precise oxygen titration than pulse oximetry alone.
Eligibility criteria
Qualifiers
Adults aged ≥19 years
Scheduled for elective lung surgery requiring one-lung ventilation
Written informed consent
Disqualifiers
Severe pulmonary hypertension.
Left ventricular systolic dysfunction.
The participant or legally authorized representative requests withdrawal from the study.
An adverse event occurs that precludes continued participation in the study.
Trial design
Treatments tested in this trial
- ORI-Guided FiO2 Titration
- Conventional SpO₂-Guided FiO₂ Titration
Treatment groups
58 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov