To determine the safety and efficacy of in situ ischemic postconditioning immediately after successful reperfusion in AIS patients underwnet EVT.
Adult (age ≥ 18 to 95 years) patients with an occlusion of the internal carotid artery or M1 or M2 segment of the middle cerebral artery,;
Patients with a score of at least 6 on the National Institutes of Health Stroke Scale (NIHSS) at admission and a score of 0 or 1 on the modified Rankin scale before the onset of stroke;
Patients with a score of at least 6 on the Alberta Stroke Program Early CT score (ASPECTS) value;
Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital
Stoke of large artery atherosclerotic origin or other determined factors (such as dissection) or tandem occlusion;
Patients underwent rescue angioplasty or stenting after thrombectomy
Patients were treated according to national guidelines for treatment of AIS, including intravenous thrombolysis, if indicated. Thrombectomy were performed according to standard techniques. The method of endovascular therapy was selected at the discretion of treating physicians and could include stent retriever and/or catheter aspiration.
Cohort
Prospective
rapid local ischemic postconditioning (RL-IPostC)
Procedure/Surgerywith 5 circules of balloon inflations in the ipsilateral internal carotid artery, each circulation includes inflation lasting 15 seconds followed by 15 seconds of deflation
functional independence
mRS 0-2
excellent functional independence
mRS 0-1
early therapeutic response
defined as a decrease in the NIHSS score of ≥10 from baseline or an NIHSS score of 0 or 1
Mortality
Mortality of 3 month after stoke onset
hemorrhagic transformation
according to European Cooperative Acute Stroke Study II criteria
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Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Lead sponsor
Zhangzhou Municipal Hospital of Fujian Province
Collaborator
