Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65+
SponsorUniversity Medical Centre Ljubljana
About this trial
The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments.
Orthostatic hypotension is defined as an excessive drop in blood pressure after standing up from a lying or sitting position. Postprandial hypotension is an excessive drop in blood pressure that occurs after eating a meal. These conditions can increase the risk of falls, fainting, loss of independence, and other health problems in older adults.
The main questions this study aims to answer are:
* How common orthostatic hypotension and postprandial hypotension are in hospitalized adults aged 65 years and older. * Whether these conditions are associated with medication use, chronic diseases, and geriatric syndromes (such as frailty, cognitive impairment, and functional decline).
Participants will:
* have blood pressure measured while lying down and standing * have blood pressure measured after a meal * undergo a comprehensive geriatric assessment, including evaluation of functional status, cognitive function, frailty, mobility, and nutritional status * provide information about medications and medical history * be followed for up to 12 months to record outcomes such as falls, syncope, hospitalization, and death
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 65 years or older
Hospitalization in internal medicine departments at the University Medical Centre Ljubljana
Duration of hospitalization ≥48 hours
Hemodynamic stability confirmed by the treating physician
Disqualifiers
Medical condition preventing study procedures (e.g., need for continuous supine position)
Inability to provide informed consent
Refusal to participate
Severe cognitive impairment or delirium
Trial population
Hospitalized adults aged 65 years and older admitted to internal medicine departments at the University Medical Centre Ljubljana.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
500 Participants
are grouped into 1 trial groupGroup A: Adults aged 65 years and older hospitalized in internal medicine departments at the University Medic
Trial outcomes
Primary outcomes
1
Prevalence of Orthostatic Hypotension and Postprandial Hypotension in Hospitalized Older Adults at Baseline
Prevalence of orthostatic hypotension and postprandial hypotension in hospitalized adults aged 65 years and older, assessed using standardized orthostatic blood pressure measurements and postprandial blood pressure measurements. Orthostatic hypotension is defined as a decrease in systolic blood pressure of ≥20 mmHg or diastolic blood pressure of ≥10 mmHg within 3 minutes of standing.
Time frame
Baseline (during index hospitalization)Secondary outcomes
1
Number of Participants with Falls
Occurrence of falls during the 12-month follow-up period.
Time frame
12 months2
Number of Participants with Syncope
Occurrence of syncope during the 12-month follow-up period.
Time frame
12 months3
Number of Participants with Functional Decline
Functional decline during follow-up, assessed based on information from medical records and clinical history.
Time frame
12 months4
Number of Participants with Hospital Readmission
Hospital readmission during the 12-month follow-up period.
Time frame
12 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: