Osteochondritis Dissecans of Knee Prospective Cohort
ConditionOsteochondritis Dissecans
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorUniversity of Pennsylvania
About this trial
The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosis of osteochondritis dissecans or focal articular cartilage defects as confirmed by x-ray or MRI
Disqualifiers
Non-confirmed diagnosis (i.e. patient does not yet have imaging confirmation)
Trial population
Patients of all ages with osteochondritis dissecans (OCD) or focal articular cartilage defects confirmed via MRI or x-ray.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Other: observational only- no intervention
Other interventionOther: observational only- no intervention
Treatment groups
3,000 Participants
are divided into 1 treatment groupGroup A: Patients with OCD1 intervention
Trial outcomes
Primary outcomes
1
IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
Time frame
baseline up to 50 years2
PEDI-IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
Time frame
baseline up to 50 yearsSecondary outcomes
1
KOOS Knee score
The Knee injury and Osteoarthritis Outcome Score (KOOS) evaluates short-term and long-term symptoms and function in subjects with knee injury and osteoarthritis.
Time frame
baseline up to 50 years2
Marx Activity Score questionnaire
Measure of physical activity at healthiest and most active state from time of taking to year prior.
Time frame
baseline up to 50 years3
Pedi-FABS Score
An eight-item scale that measures level of physical activity and fitness.
Time frame
baseline up to 50 years4
Radiographic Healing
Visualization of bone healing through x-ray images.
Time frame
baseline up to 50 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Pennsylvania
Lead sponsor
Altona Children's Hospital
Collaborator
Boston Children's Hospital
Collaborator
Children's Hospital Medical Center, Cincinnati
Collaborator
Children's Health Andrews Institute for Orthopaedics & Sports Medicine
Collaborator
Children's Healthcare of Atlanta
Collaborator
Children's Hospital Colorado
Collaborator
Children's Hospital of Philadelphia
Collaborator
Children's Hospital and Health System Foundation, Wisconsin
Collaborator
Children's Mercy Hospital Kansas City
Collaborator
Connecticut Children's Medical Center
Collaborator
Hospital for Special Surgery, New York
Collaborator
Kaiser Permanente
Collaborator
Mayo Clinic
Collaborator
National University Hospital, Singapore
Collaborator
Rady Children's Hospital, San Diego
Collaborator
Stanford University
Collaborator
Tennessee Orthopedic Alliance
Collaborator
Texas Scottish Rite Hospital for Children
Collaborator
The Rocky Mountain Hospital for Children
Collaborator
The Hospital for Sick Children
Collaborator
Göteborg University
Collaborator
University of Minnesota/TRIA Orthopaedic Center
Collaborator
Washington University School of Medicine
Collaborator
Source ClinicalTrials.gov