Premature ovarian failure, also known as primary ovarian insufficiency (POI), or premature menopause, affects 1-2% of women under 40. The diagnosis is typically made based on high levels of follicle stimulating hormone (FSH) and absent or irregular menstrual periods. It leads to infertility and menopause-like effects (hot flashes and thin bones) due to low estrogen levels. POI can result from various factors such as genetic conditions, autoimmune diseases, or previous medical treatments like chemotherapy.
Treatment of POI usually involves hormone replacement therapy and, if pregnancy is desired, assisted reproductive technologies such as in vitro fertilization (IVF) using an egg donor. However, IVF may not be an option for everyone due to personal, religious, ethical or financial reasons. Recent advances in medicine have identified ovarian tissue transplantation (OTT) as a potential solution. OTT involves transplanting either fresh or frozen ovarian tissue into the pelvic area, where it can begin functioning again. Studies in animals and humans have shown success in restoring hormonal function and even achieving pregnancies in some cases. Initial human trials of ovarian tissue transplants from another individual began with identical twins and have since expanded to include non-identical siblings with compatible tissue matches using immunosuppression. Success rates of OTT have been promising, with multiple live births reported between identical twins. Long-term studies indicate that transplanted tissue can remain functional for up to eight years. Ovarian tissue transplantation offers a promising avenue for women with POI to help restore fertility and hormonal function. Continued research and refinement of tissue techniques are essential to improve outcomes and expand access to this innovative treatment option.
This study will enroll 10 participants who will undergo ovarian tissue transplantation donated by a non-identical sister using an immunosuppression protocol at University Hospitals.
Must meet criteria for ovarian sufficiency: Menstruating; Premenopausal serum hormone (FSH, LH, estradiol, AMH) levels
Must be between the ages of 21-35 years old.
Must be genetic sister to recipient participant, which will be assessed by patient report.
Must have history of at least one healthy live birth.
History of hypertension, diabetes, or significant heart, liver, kidney or central nervous system disease.
Any medical diagnosis placing the subject at high risk of surgical complications based on the team's review of medical history.
Current smoker (smoking cessation must have occurred 3 months prior to enrollment).
History of prior malignancy except for cervical cancer in stage 1a or 1b after 3 years.
Single group
Ovarian tissue allo-transplantation
Procedure/SurgeryParticipants will receive donor ovarian tissue with immunosuppression
Time (days) from transplantation to resumption of menses as measured by patient report
Number of live births as measured by medical record report/patient report
Time (days) from transplantation to pregnancy as measured by medical record/patient report
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