Pain and Major Depressive Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorUniversity of California, Los Angeles
About this trial
This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 treatments of blinded transcranial magnetic stimulation. There is no control group as all subjects will receive some form of active treatment. Subjects are required to participate in 30-33 study visits and volunteer 40 hours of their time. Compensation for this study is $150 for completing all study activities.
Eligibility criteria
Qualifiers
All Subjects must be between 18-75 years of age
Language: Participants must speak English fluently, as demonstrated by verbal skills sufficient to answer questions at a level that assures adequate understanding of the study
Must have confirmed diagnosis of moderate Major Depressive Disorder (single or recurrent episode), minimum score of 17 on the 17-item Hamilton Rating Scale for Depression (HAM-D17). No minimal MDD duration necessary for study participation
Failure to respond to a minimum of 2 trials of antidepressant medication
Disqualifiers
Are mentally or legally incapacitated, unable to give informed consent.
Are pregnant.
Have an active suicidal intent or plan.
Have had prior Transcranial Magnetic Stimulation treatment.
Trial design
Treatments tested in this trial
- Active rTMS/Active iTBS DFPLC/Sham Pain M1
- Active rTMS/Active iTBS
Treatment groups
54 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov