Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is associated with pathological synchronous oscillations of neuronal activity (local field potential/LFP) in the cortico-subcortical network with a wide frequency range. In the present project, we propose to study cortico-subcortical oscillations and their synchronization in patients operated for PD (subthalamic deep brain stimulation (STN-DBS)) during distinct pharmacological and stimulation conditions (hypokinetic and hyperkinetic), using a simple motor task.
Male or Female
18 to 75 years-old
With idiopathic Parkinson's disease
Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation)
Be incapable of giving consent personally.
Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection.
Being pregnant or breastfeeding
Present a serious and/or decompensated somatic or psychiatric illness.
Single group
Electrophysiological recordings
Other interventionElectrophysiological recordings will be made during a motor task in four different conditions: 1. without pharmacological treatment and without stimulation (Off condition), 2. without pharmacological treatment and during stimulation (DBS condition), 3. during pharmacological treatment and without stimulation (DOPA condition), 4. during pharmacological treatment and stimulation (DOPA+DBS condition).
Cortico-subcortical electrophysiological coherence
Statistically significant difference in the cortico-subcortical electrophysiological coherence value between a movement performed in hypokinetic condition and a movement performed in hyperkinetic condition
Spectral signal power
Demonstration of a significant difference in spectral signal power between movement in hypokinetic and hyperkinetic conditions.
Effect of STN-DBS on spectral signal power
Demonstration of a significant effect of STN-DBS on spectral signal power and cortico-subcortical synchronization during movement in hypokinetic or hyperkinetic conditions
Correlation between semiological characteristics
Demonstration of a statistical correlation between semiological characteristics (hypo- and hyperkinesia, movement parameters (reaction time and movement time)) and electrophysiological characteristics.
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University Hospital, Bordeaux
Lead sponsor
Université de Bordeaux, IMN, UMR CNRS 5293
Collaborator
