PATAKESS Protocol : Clinical and Biological Analysis of Exocrine Pancreatic Tumors
ConditionExocrine Pancreatic Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Leon Berard
About this trial
PATAKESS is a monocentric non interventional cohort study (prospective (alive patients) and retrospective (dead patients with biological material from surgery and/or biopsies already collected)).
PATAKESS consists of clinical and biological analyses of exocrine pancreatic tumors. Data are derived from tumor samples taken for routine health care purposes in patients managed at Centre Léon Bérard (Lyon-France) since January 2010. The main objective is to determine correlation between biological and clinical characterizations of patients suffering from exocrine pancreatic tumor.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Male or female patient 18 age or older
Patient operated on for exocrine pancreatic adenocarcinoma at Centre Léon Bérard since 01/01/2010.
Histological diagnosis of exocrine pancreatic adenocarcinoma confirmed with surgery specimen.
Disqualifiers
Not applicable
Trial population
Patients operated on for exocrin pancreatic adenocarcinoma since January 1st, 2010.
Trial design
Design model
Cohort
Time perspective
Other
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Determination of the correlation between clinical characterizations and biological characterizations of patients suffering from exocrine pancreatic cancer
Clinical characteristics of patients are consistent with tumor response at each treatment line and disease stage at diagnosis ; Biological characteristics will describe molecular alterations of the tumor by sequencing techniques like Next Generation Sequencing (NGS)
Time frame
Up to 72 monthsSecondary outcomes
1
Comparison of different tumor stroma : from surgery specimen of primitive tumor with preoperative chemotherapy, versus from surgery specimen of primitive tumor without preoperative chemotherapy, versus from biopsies done before chemotherapy
Comparative characterization of the different stroma by immunological detection
Time frame
Up to 72 months2
Comparison of different tumor stroma : from surgery specimen of primitive tumor with preoperative chemotherapy, versus from surgery specimen of primitive tumor without preoperative chemotherapy, versus from biopsies done before chemotherapy
Comparative characterization of the different stroma by NGS
Time frame
Up to 72 months3
Comparison of healthy tissu and tumor stroma from primitive tumor versus from metastases
Comparative characterization of the different stroma by immunological detection
Time frame
Up to 72 months4
Comparison of healthy tissu and tumor stroma from primitive tumor versus from metastases
Comparative characterization of the different stroma by NGS
Time frame
Up to 72 monthsSponsors and contacts
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Source ClinicalTrials.gov