Health Trials

Pathophysiological Explorations of Red Blood Cells

ConditionRed Blood Cell Disorder
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorImagine Institute

About this trial

GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of erythropoiesis, red blood cells and iron metabolism, and to develop new therapeutic protocols capable of providing added value in terms of innovation.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

To be affected or have a family history of disease bound to the red blood cell,

For adult subjects, have signed an informed consent form,

For minor or major under legal safeguard subjects, the form must be signed by both parents (for minors) or by the legal representative,

Be affiliated to health insurance.

Disqualifiers

Being deprived of freedom

Trial population

Inclusion of patients affected by red blood cell disorder and their non affected relatives

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Biological sampling

    Other intervention

    Biological samples including blood, surgical remainder, urine,...

Treatment groups

3,750 Participants
are divided into 2 treatment groups
Group A: Affected patients1 intervention
Group B: Non affected relatives1 intervention

Trial outcomes

Primary outcomes

1

Innovative markers of spleen fonctionality

Retention rate (%) of red blood cells using Microsphiltration compared with non affected subjects

Time frame
20 years
2

Quantification of inflammation in sickle cell disease

Activation rate of circulating mastocytes (%)

Time frame
20 years
3

Markers of post-artesunate hemolysis

Concentration of pitted red blood cells at day 3

Time frame
20 years
4

Correlation between transfusion yield and the storage of red blood cell bags

Increasing in haemoglobin concentration at 6 hours post transfusion

Time frame
20 years

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Imagine Institute

Lead sponsor

Source ClinicalTrials.gov
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