Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache
ConditionPost-Dural Puncture Headache
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-40
SponsorUmeå University
About this trial
To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
Other central neurological disorders except the actual
Acute medical condition
Pregnancy
Pacemaker, or other medical implants that are not MRI-compatible
Trial population
Two different study population with PDPH and controls.
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
MRI examination
Other interventionAll included subjects will be examined with MRI
Treatment groups
160 Participants
are divided into 2 treatment groupsGroup A: Postdural puncture headache after lumbar puncture1 intervention
Group B: Postdural puncture headache after accidental dural puncture1 intervention
Trial outcomes
Primary outcomes
1
Changes in cerebral dynamics with MRI
Cerebral blood flow and CSF
Time frame
After 3 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Umeå University
Lead sponsor
Region Västerbotten
Collaborator
Source ClinicalTrials.gov