About this trial
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:
1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 40
Clinical diagnosis of knee OA with predominant medial compartment symptoms
Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
Disqualifiers
Predominant lateral compartment OA or patellofemoral-only OA
Inflammatory arthritis (RA, gout flare, etc.)
Suspected or confirmed joint infection or overlying cellulitis
Prior knee arthroplasty on the index knee
Trial design
Parallel
Treatments tested in this trial
Anteromedial Injection
Procedure/SurgeryIf randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.
Anterolateral Injection
Procedure/SurgeryIf randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.
Treatment groups
Trial outcomes
Primary outcomes
Numeric Pain Rating Scale
This survey asks patients to rate their pain on a scale from 0 to 10.
Knee Osteoarthritis and Outcome Score-Joint Replacement
This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks.
Secondary outcomes
Institutional Survey on Satisfaction with Injection
This survey asks patients to rate their satisfaction with their corticosteroid injection on a scale from 0 to 10.
Patient Global Impression of Change
This survey asks patients to rate their overall health status on a scale from 1 to 7.
Sponsors and contacts
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University of Chicago
Lead sponsor
AdventHealth
Collaborator