Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorUniversity of Chicago

About this trial

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:

1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 40

Clinical diagnosis of knee OA with predominant medial compartment symptoms

Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)

Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee

Disqualifiers

Predominant lateral compartment OA or patellofemoral-only OA

Inflammatory arthritis (RA, gout flare, etc.)

Suspected or confirmed joint infection or overlying cellulitis

Prior knee arthroplasty on the index knee

Trial design

Design model

Parallel

Treatments tested in this trial

  • Anteromedial Injection

    Procedure/Surgery

    If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.

  • Anterolateral Injection

    Procedure/Surgery

    If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.

Treatment groups

140 Participants
are divided into 2 treatment groups
Group A: AnterolateralActive comparator 1 intervention
Group B: AnteromedialActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Numeric Pain Rating Scale

This survey asks patients to rate their pain on a scale from 0 to 10.

Time frame
Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection
2

Knee Osteoarthritis and Outcome Score-Joint Replacement

This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks.

Time frame
Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection

Secondary outcomes

1

Institutional Survey on Satisfaction with Injection

This survey asks patients to rate their satisfaction with their corticosteroid injection on a scale from 0 to 10.

Time frame
2 weeks, 6 weeks, and 12 weeks post-injection
2

Patient Global Impression of Change

This survey asks patients to rate their overall health status on a scale from 1 to 7.

Time frame
2 weeks, 6 weeks, and 12 weeks post-injection

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Chicago

Lead sponsor

AdventHealth

Collaborator