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Patterns of Aortic Isthmus Doppler in Early Fetal Growth Restriction , and the Changes in Aortic Isthmus Doppler Parameters With Every Changes of Other Early Iugr Parameters Like EFW, Uterine Artery Doppler, Cerebroplacental Ratio and Ductus Venosus Doppler in Comparison With Normal Group .

ConditionsFetal Growth RestrictionPlacental InsufficiencyAortic Isthmus DopplerCerebroplacental Ratio
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-45
SponsorAssiut University

About this trial

This study aims to evaluate the patterns of aortic isthmus Doppler in fetuses diagnosed with early fetal growth restriction (FGR) and to correlate these findings with the severity of FGR and other Doppler parameters.

A cross-sectional comparative observational study will be conducted on singleton pregnant women attending the fetal medicine unit at Assiut University Hospital. Participants will be divided into two groups: fetuses with FGR and normal controls.

Doppler measurements including aortic isthmus indices, uterine artery, umbilical artery, middle cerebral artery, cerebroplacental ratio, and ductus venosus will be assessed at a single time point. The study will help to clarify the clinical value of aortic isthmus Doppler in early detection and assessment of fetal compromise in FGR cases.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Singleton pregnancy

Diagnosis of fetal growth restriction (estimated fetal weight <10th percentile for gestational age)

Written informed consent obtained from the patient

Disqualifiers

Major fetal structural anomalies, especially cardiovascular anomalies

Multiple pregnancy (e.g., twins)

Suspected chromosomal abnormalities or genetic syndromes

Severe maternal comorbidities affecting Doppler results (e.g., uncontrolled diabetes, lupus)

Trial population

Singleton pregnant women attending the fetal medicine unit at Women's Health Hospital, Assiut University, including both fetal growth restriction cases and normal controls.

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

100 Participants
are grouped into 2 trial groups
Group A: FGR Group
Group B: Control Group

Trial outcomes

Primary outcomes

1

Aortic Isthmus Pulsatility Index

Measurement of the aortic isthmus pulsatility index (PI) and its correlation with the severity of fetal growth restriction based on estimated fetal weight percentiles.

Time frame
Day 1

Secondary outcomes

1

Cerebroplacental Ratio

Measurement of cerebroplacental ratio (MCA PI / UA PI) and its correlation with aortic isthmus Doppler findings.

Time frame
Day 1
2

Ductus Venosus Doppler

Assessment of ductus venosus pulsatility index and its relationship with aortic isthmus Doppler changes in fetal growth restriction.

Time frame
Day 1
3

Uterine and Umbilical Artery Doppler

Evaluation of uterine artery and umbilical artery pulsatility indices and their association with aortic isthmus Doppler parameters.

Time frame
Day 1
4

Isthmic Flow Index

Assessment of isthmic flow index (IFI) and its association with fetal hemodynamic changes in fetal growth restriction cases.

Time frame
1 day

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: