Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorSpecialized Medical Center (SMC)
About this trial
This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery. Pneumoperitoneum and patient positioning during laparoscopic procedures can significantly affect respiratory mechanics, including airway pressures and lung compliance.
The study will assess changes in peak airway pressure, dynamic compliance, and other ventilatory parameters during different intraoperative phases. The findings are expected to provide insights into optimizing ventilatory strategies to improve patient safety and minimize ventilator-associated complications during laparoscopic surgery.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients aged 18-65 years
Scheduled for elective laparoscopic abdominal surgery under general anesthesia
ASA physical status I-II
Patients requiring mechanical ventilation using PRVC mode
Disqualifiers
Patients with significant cardiopulmonary disease
Chronic obstructive pulmonary disease or restrictive lung disease
Morbid obesity (BMI > 35 kg/m²)
Pregnancy
Trial population
Adult patients undergoing elective laparoscopic abdominal surgery under general anesthesia at a tertiary care center.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
PRVC Ventilation
Other interventionMechanical ventilation using pressure-regulated volume control mode applied as part of routine intraoperative anesthesia care. No experimental intervention is introduced.
Treatment groups
52 Participants
are divided into 1 treatment groupGroup A: Single Cohort1 intervention
Trial outcomes
Primary outcomes
1
Peak Airway Pressure
Peak airway pressure (PIP) measured intraoperatively using the anesthesia workstation under standardized pressure-regulated volume control ventilation settings.
Time frame
At 0, 5, and 10 minutes intraoperativelySecondary outcomes
1
Dynamic Compliance
Dynamic lung compliance (Cdyn) measured intraoperatively using standard anesthesia monitoring at predefined time points.
Time frame
At 0, 5, and 10 minutes intraoperatively2
Plateau Pressure
Plateau pressure (Pplat) measured during controlled ventilation using the anesthesia workstation.
Time frame
At 0, 5, and 10 minutes intraoperatively3
End-tidal Carbon Dioxide
End-tidal carbon dioxide (EtCO2) measured continuously during mechanical ventilation.
Time frame
At 0, 5, and 10 minutes intraoperatively4
Mean Airway Pressure
Mean airway pressure measured intraoperatively using the anesthesia workstation.
Time frame
At 0, 5, and 10 minutes intraoperativelySponsors and contacts
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Source ClinicalTrials.gov