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PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

ConditionsVentilation TherapyPEEP, OccultCPRCardiac Arrest (CA)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMuehlenkreiskliniken, MKK

About this trial

Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults >= 18 years

non-traumatic OHCA

mechanical ventilation via airway device

Disqualifiers

Patients < 18 years,

traumatic cause of OHCA,

no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)

Trial design

Design model

Parallel

Treatments tested in this trial

  • PEEP 5 mbar

    Procedure/Surgery

    Positiv-End-Expiratory Pressure

  • ZEEP 0 mbar

    Procedure/Surgery

    Zero-End-Expiratory Pressure

Treatment groups

600 Participants
are divided into 2 treatment groups
Group A: PEEPExperimental treatment 1 intervention
Group B: ZEEPExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

The return of spontaneous circulation (ROSC)

The primary outcome is the ROSC, defined according to the Utstein template by the presence of a palpable pulse during or after resuscitation. This will be measured as a binary outcome (palpable pulse, yes or no).

Time frame
During or after resuscitation

Secondary outcomes

1

Re-Arrest-Rate

Any need for chest compressions after ROSC (yes vs. no)

Time frame
Upon hospital admission
2

Death during pre-hospital care phase

Any death during pre-hospital care phase (yes vs. no)

Time frame
Upon hospital admission
3

Hospital admission during ongoing resuscitation

Need for chest-compressions at hospital admission (yes vs. no)

Time frame
at hospital admission
4

Hospital admission with spontaneous circulation

Hospital admission with spontaneous circulation without need for chest compressions (yes vs. no)

Time frame
at hospital admission

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Muehlenkreiskliniken, MKK

Lead sponsor

Source ClinicalTrials.gov
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