The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.
Pregnant woman
Pregnant women, 6-13^+6 gestational weeks
Resided in Weifang in the past half years and have no plan to move out after delivery
Pregnant women who plan to have antenatal care and delivery in Weifang maternal&Child Hospital.
Participants who cannot communicate normally.
Pregnant women and their children in Weifang, China
Cohort
Prospective
No Interventions
Other interventionNo intervention This is an observational study without any intervention
Numbers and morbidity of participants with pregnancy complications
Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy
Numbers and morbidity of participants with adverse pregnancy outcomes
Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects.
Weight in kilogram changes during childhood
Measured by health professionals in clinic
Height in centimeter changes during childhood
Measured by health professionals in clinic
Early Child development
Measured by Ages\&Stages Questionnaires (ASQ).There are 6 questions in each of 5 domains of development: communication, gross motor, fine motor, problem-solving skills, and adaptive skills. Each question is given a 10 (yes), 5 (sometimes), or 0 (not yet) score according to the parents' answers. The sum scores (range from 0 to 300) and scores for each domain (range from 0 to 60) are calculated. Chinese norms are available for each domain, and any domain screened \<2 SDs below the mean is considered a positive screening. A higher ASQ score means better development.
Incidence of diabetes mellitus in women
Measured by health professionals in clinic
Click on the lead sponsor to view all of their trials.
Peking University
Lead sponsor
National Natural Science Foundation of China
Collaborator
