Health TrialsbyHealthPanel

PENG Block: Continuous Infusion vs. Programmed Intermittent Bolus in Neck of Femur Fracture

ConditionsHip FractureAnalgesia Post Fracture
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity College Cork

About this trial

Pericapsular Nerve Group Block (PENG) is an effective regional anaesthesia modality in providing analgesia following neck of femur fracture. Continuous PENG techniques, using indwelling catheters and infusions of local anaesthetic, facilitate the continuation of analgesia for a number of days following hip fracture surgery. It is unclear from the published literature whether an optimal strategy of local anaesthetic delivery has been characterized.

Similar doses of local anaesthetic agents can be administered by either continuous infusion or timed intermittent bolus. It is unclear whether one dosing strategy is superior to the other in the context of hip fracture analgesia. The study aims to evaluate the clinical efficacy of both dosing strategies in patients undergoing hip fracture surgery.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

English-speaking

over the age of 18 years

hemiarthroplasty for fractured neck of femur

able to provide written consent.

Disqualifiers

under 50kg body weight.

unable to provide consent due to incapacity

pregnant women

vulnerable adults under state guardianship

Trial design

Design model

Parallel

Treatments tested in this trial

  • continuous infusion of levobupivacaine

    Other intervention

    Participants in this arm will receive a continuous infusion of levobupivacaine via a regional anaesthesia catheter placed in the PENG fascial space. The total dose over 24 hours will be equivalent in both arms of the study.

  • Programmed Intermittent Bolus of Levobupivacaine

    Other intervention

    Participants in this arm will receive a timed pre-set bolus dose of levobupivacaine via a regional anaesthesia catheter placed in the PENG fascial space. The total dose over 24 hours will be equivalent in both groups.

Treatment groups

150 Participants
are divided into 2 treatment groups
Group A: Continuous PENG InfusionActive comparator 1 intervention
Group B: Programmed Intermittent Bolus PENGExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Numeric Rating Pain Scale (NRS 0-10)

Patients will be invited to rate their post operative pain at rest and on movement on a 0-10 scale; where 0 is no pain and 10 is worst imaginable pain.

Time frame
48 Hours Post-operatively

Secondary outcomes

1

Numeric Rating Pain Scale (NRS 0-10)

Time frame
1, 2, 4, 24 hours postoperatively
2

Quality of Recovery 15 (QOR15)

Patients will be invited to complete a validated multidomain assessment of recovery following anaesthesia and surgery.

Time frame
48 hours postoperatively

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University College Cork

Lead sponsor

Source ClinicalTrials.gov
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