About this trial
The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:
* Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk? * How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits?
Researchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis.
Participants will:
* Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task. * Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials). * Provide demographic, clinical, and neuropsychological data during study visits. * For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age between 18 and 30 years
Normal or corrected-to-normal visual acuity
Affiliated with or dependent on a social security health insurance plan
Provided informed consent and co-signed the study consent form with the investigator
Disqualifiers
Pregnant, postpartum, or breastfeeding women
Individuals deprived of liberty by judicial or administrative decision
Individuals in a life-threatening emergency
Adults under legal protection measures
Trial design
Single group
Treatments tested in this trial
behavioral tasks
BehavioralAll participants will undergo behavioral assessments of visual and auditory processing, including contrast sensitivity, facial emotion recognition, visual inference using Necker cubes, tone-matching, and auditory emotion recognition.
Electroretinography
DeviceParticipants will additionally undergo electrophysiological recordings of retinal function (a-wave, b-wave, phNR, oscillatory potentials) using flash stimulation.
Comprehensive Assessment of At Risk Mental States (CAARMS)
Diagnostic testAll participants will be assessed using the CAARMS in order to evaluate their symptoms and classify them into either the CHR or FEP group
Neuropsychological tests
BehavioralTAP attention and working memory test, fNART, VOSP, Verbal fluency test.
Treatment groups
Trial outcomes
Primary outcomes
Contrast sensitivity task
computerized contrast detection task
Facial emotion recognition task
computerized emotion recognition task
Visual inference task
Computerized visual inference task
Tone matching task
Computerized tone matching task
Secondary outcomes
CAARMS assessment
Follow-up symptomatic assessment to evaluate the predictive power of sensory treatment (computerized tasks, ERG) for the risk of psychotic transition.
TAP Working Memory test
fNART
Tap attention test
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Centre Psychothérapique de Nancy
Lead sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Collaborator
This trial is not recruiting at the moment. You can still explore other options: