Perception and Integration of Sensory Information in the Early Stages of Psychosis

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-30
SponsorCentre Psychothérapique de Nancy

About this trial

The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:

* Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk? * How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits?

Researchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis.

Participants will:

* Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task. * Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials). * Provide demographic, clinical, and neuropsychological data during study visits. * For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age between 18 and 30 years

Normal or corrected-to-normal visual acuity

Affiliated with or dependent on a social security health insurance plan

Provided informed consent and co-signed the study consent form with the investigator

Disqualifiers

Pregnant, postpartum, or breastfeeding women

Individuals deprived of liberty by judicial or administrative decision

Individuals in a life-threatening emergency

Adults under legal protection measures

Trial design

Design model

Single group

Treatments tested in this trial

  • behavioral tasks

    Behavioral

    All participants will undergo behavioral assessments of visual and auditory processing, including contrast sensitivity, facial emotion recognition, visual inference using Necker cubes, tone-matching, and auditory emotion recognition.

  • Electroretinography

    Device

    Participants will additionally undergo electrophysiological recordings of retinal function (a-wave, b-wave, phNR, oscillatory potentials) using flash stimulation.

  • Comprehensive Assessment of At Risk Mental States (CAARMS)

    Diagnostic test

    All participants will be assessed using the CAARMS in order to evaluate their symptoms and classify them into either the CHR or FEP group

  • Neuropsychological tests

    Behavioral

    TAP attention and working memory test, fNART, VOSP, Verbal fluency test.

Treatment groups

294 Participants
are divided into 1 treatment group
Group A: observational behavioral and electrophysiological assessmentsExperimental treatment 4 interventions

Trial outcomes

Primary outcomes

1

Contrast sensitivity task

computerized contrast detection task

Time frame
Day 1 for healthy controls, Day 1-30 for patients
2

Facial emotion recognition task

computerized emotion recognition task

Time frame
Day 1 for healthy controls, Day 1-30 for patients
3

Visual inference task

Computerized visual inference task

Time frame
Day 1 for healthy controls, Day 1-30 for patients
4

Tone matching task

Computerized tone matching task

Time frame
Day 1 for healthy controls, Day 1-30 for patients

Secondary outcomes

1

CAARMS assessment

Follow-up symptomatic assessment to evaluate the predictive power of sensory treatment (computerized tasks, ERG) for the risk of psychotic transition.

Time frame
6 months follow up
2

TAP Working Memory test

Time frame
Day 1
3

fNART

Time frame
Day 1
4

Tap attention test

Time frame
Day 1

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Centre Psychothérapique de Nancy

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Collaborator

This trial is not recruiting at the moment. You can still explore other options: