Perception, Sensation, Cognition and Action in Humans
ConditionNormal Physiology
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age13-65
SponsorNational Eye Institute (NEI)
About this trial
Background:
When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happens. Researchers want to explore how healthy brains process sights and sounds.
Objectives:
To explore how people understand what they see and hear when the brain processes sights and sounds.
Eligibility:
Participants aged 13-65 who have at least 20/40 vision in at least one eye and do not use a hearing aid.
Design:
Some participants will take tests online anonymously. They will do computer tasks related to colors and behavior.
In-person participants will be screened with medical history and physical exam. They will complete questionnaires and vision and hearing tests. Off-site participants will be screened with questionnaires about themselves and their vision. If results indicate abnormal color vision, these off-site participants may be asked to provide saliva samples for genetic screening.
In-person participants will plan how many testing sessions they will have and when. Sessions last 2-5 hours. They may include:
* Magnetic Resonance Imaging: Magnets and radio waves to take pictures of the brain. Participants will lie on a table that slides in and out of a tube. They will do a task during the scan. * Magnetoencephalography: Records magnetic field changes from brain activity. Participants will sit or lie down. A cone will be lowered onto their head. They may do a task during the test. * Electromyography: Electrodes attached to the skin will measure the electrical activity of muscles. * Electroencephalogram: Electrodes on the scalp will record brain waves. * Electrocardiography: Electrodes on the chest will record heart electrical activity. * Tests of memory, attention, thinking, vision, and hearing. * Eye Tracking: Cameras will follow participants eye movements. They may wear a cap with infrared cameras in front of their eyes.
During the sessions, participants vital signs may be monitored.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
is in good general health;
is between 18 and 65 years old;
has visual acuity of 20/40 in at least one eye (corrected with contact lenses is okay);
has no hearing impairment requiring a hearing aid.
Disqualifiers
Participant is pregnant
Participant has serious vision or hearing problems; for some sub-studies focused on mechanisms of normal color vision, subjects who are colorblind will also be excluded;
Participants without consent capacity will not be enrolled;
Participant has a debilitating neurological disorder (examples include, but are not limited to: brain tumor, epilepsy, Alzheimer's Disease, Parkinson's Disease, multiple sclerosis) or a psychiatric disorder (examples include, but are not limited to: schizophrenia, clinical anxiety, severe depression, attention deficit hyperactivity disorder (ADHD), schizophrenia). Patients with non-debilitating conditions such as prosopagnosia, prosopometamorphosia (PMO), or aphantasia will have their conditions noted but will not be excluded);
Trial population
For in-lab testing, one hundred subjects (100) will be recruited from a healthy adult population and are expected to represent a broad cross-section of the population. One hundred (100) off-site participants will be recruited for genetic screening. For on-line testing, we anticipate up to 10,000 subjects will be recruited.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
10,200 Participants
are grouped into 3 trial groupsGroup A: In-person
Group B: Off-site
Group C: On-line
Trial outcomes
Primary outcomes
1
MRI
We will analyze the anatomical structures of the brain (structural MRI or DTI); amplitude of the BOLD signal (fMRI).
Time frame
duration of the study2
MEG
We will quantify measures such as power spectrum, event- of task-related potentials, synchronization/de-synchronization and coherence between sensors or sources located close to the brain areas of interest.
Time frame
duration of the study3
Behavioral Measures
We will quantify measures such as hit rate, reaction times, detection thresholds, eye movement patterns, color, shape and sound judgement. We may measure autonomic data during the course of the sub-study (such as heart rate, respiration, end-tidal CO2, skin conductance), which will be correlated to the outcome measures.
Time frame
duration of the studySponsors and contacts
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Source ClinicalTrials.gov