Health TrialsbyHealthPanel

Perceptual Influences From Smoking Cannabis: an Experimental Study

ConditionsCannabis UseStress
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-65
SponsorUniversity of Colorado, Boulder

About this trial

The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and heart rate.

We expect that participants will be in this research study for approximately one week. The total amount of time that participants will spend completing study tasks will be about 2.5 hours across two separate in-person visits.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

21-65 years of age

Endorsement of at least some use of cannabis for coping purposes (>1 on CMMQ)

Regularly use flower cannabis products (i.e., ≥1x/week in the last 6 months)

Proficient in English language

Disqualifiers

Diagnosis or use of medications for substance use or psychotic disorders

Report of other drug use (cocaine, opiates, methamphetamine) in the past 90 days or fail urine screen for any of these drugs

Females cannot be pregnant or trying to become pregnant or nursing mothers

Not able to provide informed consent

Trial design

Design model

Parallel

Treatments tested in this trial

  • Water Temperature Variation - WW

    Other intervention

    Participants are assigned to warm water temperature.

  • Water Temperature Variation - CW

    Other intervention

    Participants are assigned to cold water temperature and are video recorded.

Treatment groups

166 Participants
are divided into 2 treatment groups
Group A: Cold WaterExperimental treatment 1 intervention
Group B: Warm WaterPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Blood Cortisol Levels

Cortisol levels are measured in blood.

Time frame
Pre-Use/Pre-Water Task, 20 minutes Post-Use, 40 minutes Post-Use
2

Cannabis Used

Grams of product used is calculated. Product is measured before and after use to measure how much was used.

Time frame
Immediate Post-Use
3

Blood Endocannabinoid Levels

Blood levels of AEA are measured.

Time frame
Pre-Use/Pre-Water Task, 20 minutes Post-Use
4

Heart Rate

Participant HR is measured via pulse oximeter.

Time frame
Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Colorado, Boulder

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator

Source ClinicalTrials.gov
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