Performance of a Fast-track Pathway for Giant Cell Arteritis Diagnosis

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50+
SponsorGroupe Hospitalier de la Rochelle Ré Aunis

About this trial

Giant cell arteritis is a vasculitis, i.e. inflammation of the artery walls, which generally affects people over the age of 50. Diagnosis can be long and difficult, as the clinical signs are not specific (headache, pain in the jaw, scalp, shoulders and/or pelvis, abdominal pain, weight loss, etc.), but it must be made quickly, given the risk of complications.

The reference method for diagnosis was initially based on clinical suspicion and analysis of a "piece of temporal artery" (biopsy) performed in the operating theatre under local anaesthetic. Since the mid-1990s, improvements in ultrasound techniques have made it possible to identify a sign, known as a halo, on the temporal arteries that is typical of patients with Giant Cell Arteritis. A prospective multicenter study published in 2024 demonstrated that, in patients with a clinical suspicion of Giant Cell Arteritis, if a halo was found on both temporal arteries by ultrasound, there was no need for a biopsy. This study is at the origin of a change in practices in the diagnosis and care of patients suffering from this disabling disease.

To facilitate early diagnosis, a fast-track pathway has been set up. The aim is to make a rapid diagnosis, thereby reducing the risk of after-effects, shortening the length of hospital stays, considering outpatient treatment and limiting the number of biopsies.

The investigators propose to evaluate the performance of this fast-track pathway.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patient suspected of GCA

Disqualifiers

Opposition to the use of their data

Trial population

Patients from North Charente-Martime with suspicion of GCA that are sent to la Rochelle hospital for fast track diagnosis

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

100 Participants
are grouped into 1 trial group
Group A: Patient suspected of Giant Cell Arteritis

Trial outcomes

Primary outcomes

1

Performance of the Fast Track Clinic for GCA diagnosis

Number of patients for whom the delay between GCA suspicion and ultrasound result is less than 7 days

Time frame
From initial GCA suspicion by the clinician to the ultrasound result (up to day 7)

Secondary outcomes

1

Delay in starting corticosteroids

The duration between suspicion of GCA and corticosteroid prescription

Time frame
From initial GCA suspicion by the clinician to corticosteroid prescription (up to 1 month)
2

Patients with an alternative diagnosis

Number of patients with an alternative diagnosis

Time frame
From clinical suspicion to the final diagnosis (around 1 month)
3

Patients ultrasound negative and pathology positive

The number of ultrasound negative patients with a positive result according to pathology analysis of temporal artery biopsy

Time frame
From clinical suspicion to pathology results (up to 15 days)
4

GCA patients with negative ultrasound and pathology

Number of patients for whom Doppler ultrasound and biopsy analysis results are negative but who are considered to have GCA by the clinician

Time frame
From clinical suspicion to final diagnosis (around 1 month)

Other outcomes

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