Performance of Lung MRI Combined to Synthetic CT in the Follow-up of Lung Nodules
ConditionLung Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-74
SponsorUniversity Hospital, Bordeaux
About this trial
Lung cancer screening trials using low-dose chest CT scans have shown a significant reduction of cancer related mortality in subjects at high risk of lung cancer. However, high rate of false positives and overdiagnosis have led to invasive methods, which are not without risks. Evaluation of lung nodules using lung MRI with ultra short echo time sequences (UTE) has been found comparable to chest CT scans. Moreover, MRI has the advantage of multiparametric characterization of lesions using different tissue contrasts. Following the recommendation of the French National Authority for Health (HAS) to evaluate new methods of lung cancer screening, this prospective single center pilot study is designed to evaluate the performance of multiparametric lung MRI combined to synthetic CT in the diagnosis of lung cancer in heavily smokers or ex-smokers professionally exposed to carcinogens
Eligibility criteria
Qualifiers
Subject aged between 55 and 74 years
High risk of developing lung cancer: by a combination of exposure to lung carcinogens and smoking (exposure to tobacco at the rate of 30 packs/year or cessation < 15 years)
Presence of at least one lung solid nodule ≥ 5mm on the initial scan.
Subject able and willing to complete all scheduled visits and assessments.
Disqualifiers
Subject with signs of lung cancer
Subject with history of lung cancer
Presence of severe life-threatening comorbidities at 6 months (recent CVA, recent discovery of advanced stage cancer)
Subject who had already undergone a chest scan less than a year previously
Trial design
Treatments tested in this trial
- multiparametric MRI
Treatment groups
50 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov