Perfusion Index in Pediatric Low-Flow Anesthesia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age2-12
SponsorIstinye University

About this trial

This study aims to evaluate changes in perfusion index (PI) in pediatric patients undergoing elective surgery under low-flow anesthesia. PI will be monitored at multiple intraoperative and postoperative time points to assess its relationship with hemodynamic stability and depth of anesthesia. The study will also investigate whether low-flow anesthesia affects the incidence of emergence agitation (EA). Patients will be assigned to either low-flow or normal-flow anesthesia groups based on routine clinical practice. No intervention will be applied beyond standard care. The findings are expected to provide insight into the predictive value of PI in postoperative recovery and support safer anesthesia practices in pediatric populations.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA I-II pediatric patients

Age 2 to 12 years

Undergoing elective surgery lasting between 1-6 hours

Informed consent obtained from parents/guardians

Disqualifiers

Cardiovascular, respiratory, neurological, metabolic, or endocrine disorders

Premature birth with corrected age < 2 years

Obesity or severe malnutrition (BMI <5th or >95th percentile)

Psychiatric or neurodevelopmental disorders (e.g., autism)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Low-Flow Anesthesia (LFA)

    Procedure/Surgery

    General anesthesia with a fresh gas flow rate of 1 L/min (50% oxygen + 50% air).

Treatment groups

90 Participants
are divided into 2 treatment groups
Group A: Low-Flow Anesthesia Group (LFA)Experimental treatment 1 intervention
Group B: Normal-Flow Anesthesia Group (HFA)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in Perfusion Index (PI)

Perfusion Index (PI) will be measured at 11 predefined perioperative time points to assess its intraoperative variation and its potential correlation with anesthesia depth and emergence profile in pediatric patients undergoing low-flow vs normal-flow anesthesia.

Time frame
From induction to 30 minutes after extubation

Secondary outcomes

Other outcomes

Sponsors and contacts

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