This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains communicate.
Females 12-21 years old
Able to communicate and provide consent/assent
English speaking
Diagnosed with POTS (POTS will be defined standardly as a symptomatic ≥ 40 bpm rise in heart rate without a drop in blood pressure and with symptoms of orthostatic intolerance clinically)
Inflammatory arthritis, connective tissue or auto-immune disorder
Any chronic neurological disorder besides POTS
Evidence of unstable medical disorder, such as kidney (rising creatinine, or end-stage renal failure) or liver impairment (rising AST or ALT, or end-stage with coagulopathy), poorly controlled significant cardiovascular (CHF), respiratory, endocrine (diabetes - A1c > 9 - or untreated thyroid dysfunction) or uncontrolled psychiatric illness (such as untreated depression, psychosis, etc.)
Neuropathy, central nervous system disorder (e.g., Cerebral palsy, developmental delay, seizure disorder, MS, stroke, etc.)
Parallel
Looming task
BehavioralParticipants will be asked to look at some pictures during an fMRI scan. Participants will press a button as soon as they see the image appear.
Periaqueductal gray region activation - looming task
Functional magnetic resonance imaging (fMRI) will be performed to measure activation of the periaqueductal gray region during the looming task
Periaqueductal gray region activation - resting
Functional magnetic resonance imaging (fMRI) will be performed to measure activation of the periaqueductal gray region while at rest
Click on the lead sponsor to view all of their trials.
