Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial

ConditionsArthropathy of Hip Hip Arthropathy Locoregional Anesthesia Complication of Anesthesia Regional Anesthesia Morbidity Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge Opioid Consumption

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorOspedale Edoardo Bassini

About this trial

This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach. Patients will be randomized to receive either a Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block, or a PENG block combined with wound infiltration (WI).

The primary outcome is postoperative pain intensity at rest, measured by Numerical Rating Scale (NRS) at 6 hours after surgery. Secondary outcomes include dynamic pain scores at 6, 24, and 48 hours, total opioid consumption, time to first rescue analgesia, quadriceps strength, hip flexion angle, length of stay, and adverse events.

All procedures are routinely used in clinical practice and carry minimal additional risk. Safety will be continuously monitored by the Principal Investigator and the study team according to an internal Safety Monitoring Plan.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age > 18 years

Elective total hip arthroplasty

Spinal (subarachnoid) anesthesia

Written informed consent provided by the patient or by the legal guardian, if appointed

Disqualifiers

INR > 1.5

aPTT > 1.5

Platelet count < 75,000/mm³

Signs suggestive of infection at the puncture site

Trial design

Design model

Parallel

Treatments tested in this trial

PENG plus LFCN block
Procedure/Surgery
The experimental arm will be subjected to a combination of peripheral blocks: the interfascial block of the PENG and the perinervous block of the LFCN The PENG block involves deposition of local anesthetic in the fascial plane between the psoas muscle and the superior pubic ramus. The LFCN block consists of applying local anesthetic near the nerve. The LFCN lies in the subcutaneous plane deep to the fascia lata below the anterior superior ischiatic spine.
PENG plus WI
Procedure/Surgery
The control arm will receive a combination of pericapsular nerve group (PENG) block and wound infiltration (WI). The PENG block involves the deposition of local anesthetic in the fascial plane between the psoas tendon and the superior pubic ramus, under ultrasound guidance. The wound infiltration consists of the administration of local anesthetic into the subcutaneous tissue along the surgical incision

Treatment groups

102 Participants

are divided into 2 treatment groups

Group A: PENG - LFCN BlockExperimental treatment 1 intervention

Group B: PENG-WIActive comparator 1 intervention