Health TrialsbyHealthPanel

Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis

ConditionKnee Osteoarthritis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40-65
SponsorAnkara Training and Research Hospital

About this trial

This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Symptomatic knee osteoarthritis

Clinical/radiological diagnosis

Knee pain ≥ 3 months

Written informed consent

Disqualifiers

Prior knee surgery

Recent intra-articular injection

Inflammatory rheumatic disease

Severe systemic or neurological disease

Trial population

Adult patients aged 40 to 65 years with symptomatic knee osteoarthritis who are receiving perineural injection therapy as part of routine clinical care. Eligible participants include both male and female patients who meet the predefined inclusion and exclusion criteria and are able to provide written informed consent.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Perineural 5% Dextrose Injection

    Procedure/Surgery

    Perineural injection of 5% dextrose solution administered around periarticular sensory nerves of the knee as part of routine clinical practice.

  • Perineural Local Anesthetic Injection

    Procedure/Surgery

    Perineural injection of local anesthetic administered around periarticular sensory nerves of the knee as part of routine clinical practice.

Treatment groups

86 Participants
are divided into 2 treatment groups
Group A: Perineural 5% Dextrose Group1 intervention
Group B: Perineural Local Anesthetic Group1 intervention

Trial outcomes

Primary outcomes

1

Change in Knee Pain Intensity (Visual Analog Scale [VAS])

Change in Knee Pain Intensity (Visual Analog Scale \[VAS\]) Change from baseline in knee pain intensity measured using the Visual Analog Scale (VAS), a 100-mm horizontal line anchored at 0 = no pain and 100 = worst imaginable pain; higher scores indicate worse pain.

Time frame
Baseline, 1 month, 3 months, and 6 months

Secondary outcomes

1

Change in Functional Status (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC])

Change from baseline in WOMAC total score (and/or subscales: pain, stiffness, and physical function) assessing knee osteoarthritis-related symptoms. The WOMAC consists of 24 items with a total score ranging from 0 to 96; higher scores indicate worse symptoms and worse functional status.

Time frame
Baseline, 1 month, 3 months, and 6 months
2

Change in Knee Range of Motion

Change in knee joint range of motion measured using goniometry.

Time frame
Baseline, 1 month, 3 months, and 6 months
3

Change in Quadriceps Muscle Strength

Change in quadriceps muscle strength assessed by manual muscle testing.

Time frame
Baseline, 1 month, 3 months, and 6 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ankara Training and Research Hospital

Lead sponsor

Source ClinicalTrials.gov
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