PERIodontal Disease, Microbiota and Miscarriage
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
AgeUp to 18
SponsorUniversity Hospital, Toulouse
About this trial
Cross-sectional non-interventional observational pilot study recruiting women whom had repeated miscarriages (= at least 3 miscarriages).The information will be collected during a routine maintenance, complete oral clinical and radiological examination (assessment carious, periodontal, mucosal and functional), which is part of the routine assessment in the service of odontology from Toulouse University Hospital.
Saliva and subgingival plaque samples, classically carried out in routine dental surgery as part of the health check-up oral, will be used to carry out bacterial assays.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
women whom had repeated miscarriages
at least 6 natural teeth
Disqualifiers
under antibiotic prebiotic or probiotics treatment one month prior to the study
with high infection risk (HIV,...)
Trial population
women whom had repeated miscarriages : at least 3
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
biological sampling
Other interventionAs part of the health check-up oral, Will be taken: * Salivary samples by sputum. * Samples of subgingival plaque in the periodontal sulcus * A collection of the history and disease risk factors will then be carried out. * periodontal problems by a routine care interview, the clinical examination and radiological examination.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
average quantity of Porphyromonas gingivalis
estimate the average quantity of Porphyromonas gingivalis (Pg) in saliva patients who have had recurrent miscarriages (3 consecutive miscarriages \< 14 weeks of amenorrhea)
Time frame
AT INCLUSION = T0Secondary outcomes
1
microbiological composition
microbiological composition of the saliva in women having had repeated miscarriages : Salivary samples by sputum (1 per patient). The patient will retain her saliva for 1 minute in the mouth and it will be collected in a sterile bottle (approximately 5 ml).
Time frame
AT INCLUSION = T02
microbiological composition
microbiological composition of the subgingival plaque in women having had repeated miscarriages Samples of subgingival plaque in the periodontal sulcus (assessed during periodontal probing) using sterile paper points (minimum 3 and maximum 10 per patient) inserted for 30 seconds into the periodontal sulcus then put in a tube sterile. The plate collection is done by capillary action on the paper tip, a very small quantity is thus taken.
Time frame
AT INCLUSION = T0Sponsors and contacts
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Source ClinicalTrials.gov