The purpose of this clinical trial is to understand whether the combination of periodontal initial treatment under local anesthesia and glucocorticoids can improve the effectiveness of treatment for erosive oral lichen planus. It will also understand the safety of this treatment regimen.
This study is a single-center, parallel-group, randomized self-controlled trial. The researchers will compare the treatment of periodontal initial therapy combined with glucocorticoid therapy under local anesthesia with traditional glucocorticoid therapy to see if the treatment of periodontal initial therapy combined with glucocorticoid therapy under local anesthesia promotes the healing of erosive oral lichen planus.
Participants will:
One side received periodontal initial treatment combined with glucocorticoid under local anesthesia, while the other side received traditional glucocorticoid therapy Clinical examination at 2, 4, 8, and 12 weeks after treatment Note down the size of their erosion lesion area and periodontal clinical parameters
Existence of erosive oral lichen planus that lasts for more than 2 months
Erosive lesions are located in the buccal mucosa and gingival buccal sulcus of the bilateral mandibular posterior teeth area
The erosive lesions are mild to moderate (single or multiple small area erosions; 3mm ≤ longest diameter ≤ 10mm; 9mm2 ≤ total area of erosions ≤ 100mm2), and the degree of erosion on both sides is similar (the difference in the size of erosion on both sides does not exceed ± 25%)
The plaque index in the area of erosive lesions is ≥ 3; Dental calculus index ≥ 2; Gingival index ≥ 2;
Pregnant women, lactating women, or women planning to conceive during the trial period
Patients with coagulation dysfunction or other uncontrolled systemic diseases who cannot undergo periodontal treatment
Has undergone basic periodontal treatment within the past 6 months
Individuals with a history of allergy to local anesthetic drugs such as articaine
Parallel
Periodontal initial treatment under local anesthesia
Other interventionRemoval of plaque retention factors, supragingival scaling and subgingival scraping under local anesthesia with articaine (combined with manual and ultrasound methods), and polishing
Glucocorticoid Therapy
DrugLocal blockade therapy with Betamethasone Sodium Phosphate Injection (containing 1.4mg Betamethasone equivalent), local use of 1% Triamcinolone Acetate Ointment, and rinsing with 1% Sodium Bicarbonate (avoiding systemic use during visits)
oral hygiene instruction
BehavioralInstructions and demonstrations for using manual toothbrushes Instructions and demonstrations for using dental floss or interdental brushes
The erosion area of oral lichen planus
The erosion area of oral lichen planus
visual analogue scale
Mark a horizontal line of 0-10cm on paper with a ruler, and determine the score in millimeters (mm). The score range is 0-100mm, with higher scores indicating greater pain intensity
Clinical score of oral lichen planus
probing depth
clinical attachment loss
complication
Infection, bleeding, liver and kidney damage, difficulty eating due to pain
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This trial is not recruiting at the moment. You can still explore other options:
