Peripartum Mental Health Cohort Study in Guangzhou
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
AgeNot listed
SponsorGuangzhou Women and Children's Medical Center
About this trial
The purpose of this study is to determine the incidence,development trajectory and risk factors of the main peripartum mental health problems as well as explore its adverse outcomes.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Pregnant women with <20 weeks of gestation
Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
Permanent residents or families intended to remain in Guangzhou with their child for more than 3 years
Disqualifiers
Combined with heart disease, hypertension, diabetes or hyperthyroidism
Taking anti-depressants and other treatments for depression
Participants was in infection status when the biological samples were collected
Trial population
Pregnant women before 20 weeks of gestation
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Change of prevalence of maternal prenatal depression
Using Self-rating Depression Scale (SDS) to assess maternal depressive symptoms during pregnancy. SDS scores ≥53 is defined as prenatal depressive symptoms.
Time frame
before 20th gestational week, after 33th gestational week and prior to delivery2
Change of prevalence of maternal postpartum depression in the first year after delivery
Using Edinburgh Postnatal Depression Scale (EPDS) to assess postpartum depressive symptoms. EPDS scores ≥13 is defined as postpartum depressive symptoms.
Time frame
6 weeks, 6 months and 1 year after deliverySecondary outcomes
1
Change of prevalence of maternal anxiety during pregnancy
Using Self-rating Anxiety Scale (SAS) to assess maternal anxiety during pregnancy. SAS scores ≥50 is defined as anxiety.
Time frame
before 20th gestational week, after 33th gestational week and prior to delivery2
Level of maternal cortisol during pregnancy
Using women's blood samples to test the concentration of cortisol.
Time frame
During period of 2-3 trimesters of pregnancy3
Levels of maternal inflammatory factors during pregnancy
Using women's blood samples to test the concentration of inflammatory factors, including CRP, IL-6, TNF-α, etc.
Time frame
During period of 2-3 trimesters of pregnancy4
Prevalence of preterm birth, small for gestational age, low birth weight
Obtained from electronic medical records.
Time frame
At deliverySponsors and contacts
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Source ClinicalTrials.gov