Peripheral pULSe Assessment and Arterial pRessure (PULSAR)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRegion Stockholm
About this trial
This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending circulatory failure. Peripheral pulse palpation is routinely used in emergency medicine, trauma care, critical care, and cardiopulmonary resuscitation as a rapid clinical assessment of circulation. However, the association between palpable pulses and actual arterial blood pressure remains poorly validated.
Patients treated in emergency departments, intensive care units, operating rooms, and other acute care settings will undergo routine pulse palpation at predefined anatomical locations including carotid, femoral, and radial arteries. Simultaneously measured non-invasive and/or invasive arterial blood pressure values will be recorded from routine clinical monitoring systems. Additional clinical variables relevant to circulatory status will also be collected.
The study seeks to define blood pressure thresholds associated with pulse palpability and evaluate the agreement between invasive and non-invasive blood pressure measurements in patients with circulatory shock.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Clinical signs of circulatory shock or impending circulatory failure
Availability of non-invasive and/or invasive arterial blood pressure monitoring
Pulse palpation possible without interfering with emergency care
Disqualifiers
Peripheral vascular conditions preventing reliable pulse palpation
Major extremity amputation affecting assessment sites
Clinical situations where study procedures interfere with life-saving treatment
Trial population
Adult patients with circulatory shock or impending circulatory failure treated in emergency departments, intensive care units, operating rooms, trauma centers, and other acute care settings.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Peripheral Pulse Palpation
Procedure/SurgeryManual palpation of carotid, femoral, and radial pulses performed during routine clinical care in patients with circulatory instability. Simultaneous arterial blood pressure measurements are recorded from standard monitoring systems. No study-specific treatment or intervention is administered.
Treatment groups
5,000 Participants
are divided into 1 treatment groupGroup A: Patients With Circulatory Shock1 intervention
Trial outcomes
Primary outcomes
1
Association between palpable pulses and systolic arterial blood pressure
Relationship between palpable carotid, femoral, and radial pulses and simultaneously measured systolic arterial blood pressure.
Time frame
During episodes of circulatory instability, up to 24 hours after inclusionSecondary outcomes
1
Mean arterial pressure associated with pulse palpability
Relationship between pulse palpability and mean arterial pressure (MAP).
Time frame
During episodes of circulatory instability, up to 24 hours after inclusion2
Agreement between non-invasive and invasive blood pressure measurements
Agreement between oscillometric non-invasive blood pressure and invasive arterial blood pressure measurements.
Time frame
During episodes of circulatory instability, up to 24 hours after inclusion3
Effect of vascular disease and vasoactive medication on pulse palpability
Influence of peripheral vascular disease, atherosclerosis, age, and vasoactive medications on pulse palpability.
Time frame
During hospital admission, up to 30 daysSponsors and contacts
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Source ClinicalTrials.gov