Peripheral Tissue Perfusion in Intensive Care
ConditionAcute Circulatory Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris
About this trial
Tissue perfusion has been identified as an early prognosis factor in patients admitted to intensive care. However, little is known about the effects of different hemodynamic interventions performed in clinical routine on peripheral tissue perfusion.
The aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention (fluid challenge, vasopressor or inotropic drug).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients in intensive care unit with acute circulatory failure related to sepsis or cardiac failure requiring therapeutic intervention
Disqualifiers
Agitation
Hemorrhagic shock
Severe skin lesions
Trial population
Patients in intensive care unit with acute circulatory failure related to sepsis or cardiac failure requiring a therapeutic intervention (fluid challenge or vasopressor or dobutamine)
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
180 Participants
are grouped into 3 trial groupsGroup A: Fluid challenge
Group B: Vasopressors
Group C: Inotrope
Trial outcomes
Primary outcomes
1
Skin blood flow variations
Measurement using laser doppler probe in the finger tip
Time frame
continuous monitoring during 1 hour maximum starting just before interventionSecondary outcomes
1
Capillary refill time
Clinical measurement at bedside
Time frame
at baseline, 3 timepoints after starting interventions (10, 30 and 60 minutes)2
Mottling score
Clinical measurement at bedside
Time frame
at baseline, 3 timepoints after starting interventions (10, 30 and 60 minutes)3
correlation between Skin blood flow and CRT (baseline and variations)
Measurement using laser doppler probe in the finger tip
Time frame
at baseline, at 10, 30 and 60 minutes after intervention4
correlation between skin blood flow and Cardiac output
Laser doppler with skin probe and echocardiography
Time frame
at baseline, at 10, 30 and 60 minutes after interventionSponsors and contacts
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Source ClinicalTrials.gov