Personalised Prediction of Disease Course in Ulcerative Colitis Using Multimodal Machine Learning - Part of the Presager Project

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCopenhagen University Hospital, Hvidovre

About this trial

In patients achieving clinical remission following a flare, artificial intelligence can reliably predict a new flare within the next 12 months utilizing clinical and objective information at day 0 and week 8.

Secondary endpoints:

* An artificial intelligence model's precision in predicting a new flare within 2 and 3 years * An artificial intelligence model's precision to rule out patients who will not experience a new flare within 1, 2 and 3 year

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Signed informed consent

Diagnosis of UC for at least 1 year

Relapse due to UC.

First endoscopic and histological evaluation of the flare

Disqualifiers

Well-founded doubt that the flare is due to other than the patients UC

Trial population

This is a prospective cohort of a total of 400 UC patients with an active flare

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Deep learning model

    Other intervention

    Use of deep learning model to predict individual patients disease course

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Flare I

Evaluate the accuracy in predicting a flare within 1 year after the patient's initial flare using machine learning methods.

Time frame
within 1 year

Secondary outcomes

1

Flare II

Evaluate the accuracy in predicting a flare within 2 years, after the patient's initial flare, using machine learning methods.

Time frame
within 2 years
2

Flare III

Evaluate the accuracy in predicting a flare within 3 years, after the patient's initial flare, using machine learning methods.

Time frame
within 3 years

Other outcomes

Sponsors and contacts

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