About this trial
This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 65
Receiving VA primary care
Community-dwelling
Motoric Cognitive Risky Syndrome i. Slow gait speed ii. Subjective cognitive concerns/complaints
Disqualifiers
Non-English speaking
Presence of a terminal disease
Major medical problem
Myocardial infarction or major surgery in the previous 3 months
Trial design
Sequential
Treatments tested in this trial
Functional Power Training (FPT)
BehavioralParticipants will receive twice weekly FPT, a progressive functional-based exercises that target optimizing leg force production and leg velocity.
Music-Based Digital Therapy (MBDT)
BehavioralParticipants will receive twice weekly MBDT, a technology-driven gait training that is grounded in evidence-based rehabilitation treatment, rhythmic auditory stimulation.
FPT + MBDT
BehavioralFor non-responders who were randomized to augment treatment, they will receive combined FPT and MBDT treatment.
Treatment groups
Trial outcomes
Primary outcomes
Enrollment/Baseline
Enrollment will be defined as the number of participants who were recruited and consented to the study.
Retention
Retention will be defined as the number of participants who completed the 12-week exercise treatment.
Compliance
Compliance will be defined by the proportion of completed treatment sessions.
Acceptability
Acceptability will be recorded by conducting interviews with participants who completed the 12-week exercise treatment.
Secondary outcomes
Gait Speed
Change in gait speed will be assessed after 12-week exercise treatment.
Other outcomes
Cognition - Executive Function
Change in executive function will be assessed after 12-week exercise treatment using Delis-Kaplan Executive Function System.
Sponsors and contacts
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