The purpose of this research is to see how effective the Personalized obstructive sleep apnea (OSA) Treatment Adherence Model called PRAISE is in helping the patient stick to the physician recommended OSA treatment plan Positive Airway Pressure (PAP).
Self-reported race/ethnicity as African American, African, Caribbean or black
Ages 60-85 years
accessible by phone
OSA diagnosis
progressive illnesses in which disability or death is expected within 1 year
impaired cognitive/ functional ability precluding participation
intention to move within the year
and a family member currently enrolled.
Parallel
Standard of Care
Other interventionParticipants in this group will receive standard of care treatment for sleep apnea.
Personalized OSA Treatment
BehavioralParticipants in this group will receive standard of care treatment plus the personalized treatment that consists of videos approximately three minutes long, virtual, accessed through web based application, that the participant watches weekly. The purpose of the video is tailored educational content for sleep apnea.
Proportion of participants adherence to OSA treatment
The proportion of participants who answer yes (meaning a participant acknowledges an average of more than 4 hours of continuous positive airway pressure use) or no (meaning a participant acknowledges an average of less than 4 hours of continuous positive airway pressure use).
Change in Molecular Biomarkers
The molecular biomarker are C₂N, Homocysteine, Neurofilament light, Glial fibrillary acidic protein, Tau, and Amyloid-Beta peptides and the inflammatory markers are Interleukin-6,Interleukin -10, and Tumor Necrosis Factor-alpha. All will be measured in picograms per milliliter.
Change in Vascular Markers
Red Blood Cell Count, White Blood Cell Count, and Platelet Count will be measured. All will be measured in Cells/L.
Change in Cardiometabolic Biomarkers measured in mg/dl
Total Cholesterol, HDL, LDL, Triglycerides, Bilirubin, Blood Urea Nitrogen (BUN), Calcium, Creatinine, and Glucose. Measured in milligrams/deciliter (mg/dl) assessed with blood analyses.
Change in Cardiometabolic Biomarkers as measured in grams per deciliter
Hemoglobin, Albumin, and Total Protein. Measured in grams per deciliter assessed with blood analyses.
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University of Miami
Lead sponsor
National Institute on Aging (NIA)
Collaborator
