Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorNorthwestern University

About this trial

This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the approach/avoidance behavior. TBS will be personalized based on the prefrontal theta rhythm captured with electroencephalography (EEG). The main questions it aims to answer are: 1. does a single session of personalized TBS synchronized with the individual theta rhythm over the left prefrontal cortex results in the outlasting changes in the individual behavior? 2. Does TBS results in the brain rhythms' changes as measured using resting-state EEG?

Eligibility criteria

Qualifiers

Participants must be legal adults between the ages of 18 to 65;

Able and willing to complete study procedures and tasks.

Disqualifiers

History or evidence of chronic neurological or mental disorder;

Chronic condition that requires pharmacological treatment over the course of study participation;

Pregnancy or breastfeeding;

History or evidence of alcohol or drug addiction;

Trial design

Treatments tested in this trial

  • TBS-EEG
  • TBS-EEG / Spatial Control
  • TBS / Temporal Control
  • TBS-EEG / Dose Control

Treatment groups

26 Participants
are divided into 4 treatment groups

Sponsors and collaborators

Northwestern University

Lead sponsor

National Institute of Mental Health (NIMH)

Collaborator