Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorZhongda Hospital
About this trial
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
age ≥18 years
Moderate-to-severe ARDS as per the 2023 ESICM definition
Undergoing invasive mechanical ventilation
Planned prone position based on the attending physicians' decisions
Disqualifiers
age ≥85 years
Pregnancy
Severe hemodynamic instability (> 30% increase in vasopressors in the last 6 hours or norepinephrine > 0.5 µg/kg/min)
Clinically suspected elevated intracranial pressure (>18 mm Hg)
Trial population
Intubated mechanically ventilated ARDS patients.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Ventilation-perfusion matching (V/Q match%)
corresponding to the pixels that are both ventilated and perfused divided by the total number of pixels ventilated and/or perfused
Time frame
Through study completion (within 24 hours)Secondary outcomes
1
percentage of dead space
corresponding to the ventilated but nonperfused pixels divided by the total number of pixels ventilated and/or perfused
Time frame
Through study completion (within 24 hours)2
percentage of shunt
corresponding to the perfused but nonventilated pixels divided by the total number of pixels ventilated and/or perfused
Time frame
Through study completion (within 24 hours)3
Respiratory system compliance
The compliance of respiratory system
Time frame
Through study completion (within 24 hours)4
PaO2/FiO2 ratio
PaO2/FiO2 ratio
Time frame
Through study completion (within 24 hours)Sponsors and contacts
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Source ClinicalTrials.gov