PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJohns Hopkins University

About this trial

Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resolution-CT (UHR-CT) in patients with suspected coronary artery disease. For this purpose, the investigators plan to include 33 patients with symptoms concerning for CAD who have been referred for cardiac CT testing.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Male or female patients

18 years or older

referred for coronary CT angiography because of suspected coronary heart disease (CHD) with stable symptoms

Disqualifiers

The patient has a history of coronary heart disease, defined by prior myocardial infarction or prior coronary artery revascularization.

Pregnancy.

Atrial fibrillation.

Morbid obesity defines as a body mass index of >40.

Trial design

Design model

Single group

Treatments tested in this trial

  • PET/CT

    Diagnostic test

    Experimental test for detecting atherosclerosis

Treatment groups

33 Participants
are divided into 1 treatment group
Group A: Main groupOther 1 intervention

Trial outcomes

Primary outcomes

1

Correlation of atheroma volume [mm3]

Coronary atheroma volume by PET/CT vs. CT total atheroma volume

Time frame
60 days
2

Diagnostic accuracy of detecting coronary atherosclerosis

PET/CT Sensitivity to detect any atherosclerosis by CT angiography

Time frame
60 days

Secondary outcomes

Other outcomes

Sponsors and contacts

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