Pharmaco-proteomic Platform to Evaluate Drug Interactions in Liver Transplant Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPontificia Universidad Catolica de Chile
About this trial
The goal of this observational study is to enhance the ability to forecast kidney failure in liver transplant patients in the ICU under multidrug treatment by developing a computer platform that integrates mathematical models of drug interactions, proteomics, and clinical data. The main outcomes it aims to develop are:
1. Design the multidrug web computing platform with available information on drug pair interactions (DDIs). 2. Integrate the proteomic and clinical data of liver transplant patients into the IT platform. 3. Implement the multidrug web platform to predict the clinical evolution of liver transplant patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Liver transplant patients undergoing surgery at UC Christus Hospital
Disqualifiers
Patients on renal replacement therapy
Patients for whom no clinical or pharmacological registry is available
Trial population
Liver transplant patients admitted to intensive care after surgery
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Multi-drug interaction
Other interventionThe clinical impact associated with the use of multiple drugs in liver transplant patients during their stay in ICU will be evaluated.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Develop a web platform that combines information on interactions between multiple drugs and proteomic and clinical profiles, to predict the clinical evolution in liver transplant patients hospitalized in the ICU
Periodic developmental assessments will be carried out (Analysis of drug interaction graphs, Design of the interaction web platform, Integration of omics and clinical data into the web platform)
Time frame
18 to 24 monthsSponsors and contacts
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Pontificia Universidad Catolica de Chile
Lead sponsor
Universidad de Valparaiso
Collaborator
Universidad Adolfo Ibañez
Collaborator
Source ClinicalTrials.gov