This study is a single-center, non-randomized, open-label, parallel-group, multiple-dose Phase I clinical trial evaluating the pharmacokinetic characteristics of ammoxetine hydrochloride enteric-coated tablets in participants with normal renal function and moderate renal impairment. The study enrolls 16 participants divided into two groups: Group A (participants with normal renal function) and Group B (participants with moderate renal impairment). Participants in both groups receive 60 mg of ammoxetine hydrochloride enteric-coated tablets daily at 1 hour after meals, from day 1 to day 6. Blood samples for pharmacokinetic (PK) analysis, urine samples, and safety parameters are collected before and after dosing according to the trial protocol.
Adults aged 18 ~ 75 years (inclusive), regardless of gender
Body weight ≥ 45.0 kg (female) or ≥ 50.0 kg (male), body mass index (BMI) in the range of 19 ~ 32 kg/m2 (inclusive);
Participants whose medical history, vital signs, physical examination, laboratory tests (hematology, blood biochemistry, urinalysis, coagulation function, infectious disease screening, and other relevant tests), Chest X-ray and other examination must be deemed suitable for participation in this study by the investigator;
Participants and their partners must use effective contraception (such as condoms or an intrauterine device) from 2 weeks prior to screening until 6 months after the end of the study, unless they have already undergone permanent sterilization procedures, such as bilateral tubal ligation or vasectomy; furthermore, they must not donate sperm or eggs.
Individuals with a history of allergies (allergic to two or more drugs, foods, or pollens);
Individuals with major psychiatric disorders, neurological disorders, or other systemic diseases that the investigator deems may affect trial results;
Participants who have had a severe infection or trauma within 4 weeks prior to screening, or who have undergone surgery (e.g., gastrectomy) that may affect drug absorption, distribution, metabolism, or excretion, or who are scheduled for surgery or hospitalization for other reasons during the trial period;
Participants who have experienced any of the following cardiovascular or cerebrovascular events within 6 months prior to screening: severe/unstable angina, myocardial infarction, symptomatic congestive heart failure (NYHA Class II-IV), a history of clinically significant supraventricular or ventricular arrhythmias requiring treatment or intervention, or left ventricular dysfunction; transient ischemic attack or cerebrovascular accident (e.g., stroke);history of coronary artery bypass grafting or coronary stenting, or other cardiovascular diseases, and who are deemed unsuitable for participation in this clinical trial by the investigator;
Single group
ammoxetine hydrochloride enteric-coated tablets
DrugOral administration; 60 mg
Area under the concentration vs. time curve for one dosing interval at steady-state (AUCtau,ss)
Maximum concentration observed during dosing interval at steady-state (Cmax,ss)
The incidence of adverse events (AEs)
Minimum concentration observed during dosing interval at steady-state (Cmin,ss)
Half-Life (t1/2)
Mean concentration observed during dosing interval at steady-state (Cav,ss)
Click on the lead sponsor to view all of their trials.
