A Study to Evaluate the Absorption, Distribution, Metabolism, and Excretion of [14C]-MRM-3379

Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexMale
Age18-55
SponsorMirum Pharmaceuticals, Inc.

About this trial

This is a Phase 1, open label study in healthy male participants to study the Absorption, Distribution, Metabolism, and Excretion of \[14C\]-MRM-3379 drug following a single oral dose.

Eligibility criteria

Qualifiers

Male of any race, between 18 and 55 years of age, inclusive.

Body mass index between 18.0 and 32.0 kg/m2, inclusive, and a body weight between 50 and 110 kg, inclusive.

In good health, as determined by medical history, and as assessed by the investigator (or designee).

Able to comprehend and are willing to sign the ICF and abide by the trial restrictions.

Disqualifiers

History of or current medical condition that would place the participant at risk from study participation.

Administration of any vaccine within 30 days prior to dosing.

Use or intend to use any medications/products known to alter drug absorption, metabolism, or elimination processes, including St. John's wort, within 30 days prior to dosing, considered to potentially impact participant safety or the objectives of the trial, as determined by the investigator (or designee).

Participation in a clinical trial involving administration of an IMP (new chemical entity) in the past 30 days or 5 half-lives of that drug (if known) prior to dosing, whichever is longer.

Trial design

Treatments tested in this trial

  • [14C]-MRM-3379

Treatment groups

8 Participants
are divided into 1 treatment group

Sponsors and collaborators