A Study of CTX340 in Participants with Uncontrolled Hypertension.
Age: ≥18 and ≤75 years.
Body mass index ≤40 kg/m2.
24-hour mean ambulatory blood pressure monitoring (ABPM) systolic blood pressure (SBP) measurement of ≥130 mm Hg but ≤160 mm Hg despite treatment
Be on treatment with ≥4 antihypertensive therapies at effective doses, of which ≥1 must be a diuretic.
Serum aldosterone and direct renin concentration (or plasma renin activity [PRA]) suggestive of primary aldosteronism
Mean diastolic blood pressure (DBP) ≤65 mm Hg on screening ABPM.
Participants with vascular cause of hypertension which may be amendable to revascularization
Participants with treatable/reversible causes of uncontrolled hypertension