This is a clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamic and immunogenicity of single subcutaneous injection of SHR-4658 in healthy volunteers and volunteers with elevated blood pressure.
Able and willing to provide a written informed consent.
Blood pressure as defined in the protocol.
Male or female，aged 18 to 55 years (inclusive).
Meet the weight standard.
Known history or current clinically significant disease.
Protocol-defined risk factors for disease.
Participated in clinical trials of other drugs or medical devices.
Pregnant or nursing women.
Parallel
SHR-4658 Injection.
DrugSHR-4658 injection.
SHR-4658 Placebo Injection
DrugSHR-4658 placebo injection.
Adverse events (AEs)
Area under the concentration-time curve from time 0 to the last time point (AUC0-last)
Area under the concentration-time curve from time 0 to infinity (AUC0-inf)
Maximum observed concentration (Cmax)
Time to maximum observed concentration (Tmax)
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This trial is not recruiting at the moment. You can still explore other options:
