Allogeneic iNKT Cell Therapy (agenT-797) After SCT

Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Wisconsin, Madison

About this trial

The goal of this clinical trial is to learn if agenT-797 is safe to use on people undergoing allogenic hematological stem cell transplantation (SCT). The main questions it aims to answer are:

* Is agenT-797 safe to use? * What medical problems do participants have when taking agenT-797?

Participants will receive an infusion of agenT-797 about 7 days after their allogenic SCT.

Eligibility criteria

Qualifiers

Age ≥18 years at the time of consent

Adult patients anticipated to get an allogeneic hematopoietic cell transplantation (allo-SCT)

All donor types are accepted (MMUD [mismatched unrelated donor], MUD [matched unrelated donor], MSD [matched sibling donor], haploidentical)

All conditioning regimens will be accepted (MAC [myeloablative conditioning], RIC [reduced-intensity conditioning], NMAC [non-myeloablative conditioning])

Disqualifiers

Excluded Diagnoses: Primary Myelofibrosis in the dose escalation phase and could be included in the dose-expansion phase

Trial design

Treatments tested in this trial

  • agenT-797

Treatment groups

22 Participants
are divided into 1 treatment group