Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexFemale
Age25-65
SponsorLiaquat National Hospital & Medical College

About this trial

The goal of this study is to know how effectively TAP block can reduce postoperative pain in total abdominal hystrectomy patients when given ketamine in addition to bupivacaine in TAP block and to compare it with the conventional TAP block with bupivacaine only. The main question it aims to answer is:

Does intervention with ketamine in TAP block lowers the postoperative pain measured via visual analog scale and decreases the need for rescue analgesia?

Patients will be assessed for pain in PACU( post anesthesia care unit), 6 hours, 12 hours and 24 hours postoperatively. Time of rescue analgesia will also be noted if given.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged between 25 to 60 years.

ASA grade I & II.

Undergoing total abdominal hysterectomy.

Disqualifiers

BMI >35kg/m2.

Patient refusal for participation.

Patients with coagulation disorders.

Patents with history of allergy and hypersensitivity to local anesthetic.

Trial design

Design model

Parallel

Treatments tested in this trial

  • bupivicaine 0.25%

    Drug

    20ml of 0.25% bupivacaine inTAP block

  • bupivicaine 0.25% + ketamine

    Drug

    20ml of 0.25% of bupivacaine with 50mg ketamine in TAP block

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: TAP block with bupivacaine onlyActive comparator 1 intervention
Group B: TAP block with bupivacaine plus ketamineExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

VAS score

VAS (visual analog scale ) score noted VAS of \<2 = no pain VAS of 2-4 = mild pain VAS of 5-6 = moderate pain VAS of \>6 = severe pain

Time frame
At PACU(5 mins after shifting to PACU), 6,12 and 24 hours post-operatively
2

Time of receiving first rescue analgesia

time for additional requirment of inj. tramadol 50mg for post operative pain relief

Time frame
within first 24 hours postoperatively

Secondary outcomes

Other outcomes

Sponsors and contacts

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